Diagnostic Performance of F-18 FDG PET/CT Compared with CA125, HE4, and ROMA for Epithelial Ovarian Cancer
| Autor: | Ji Sun Park, Seok Mo Lee, Dae Hoon Jeong, Jung Mi Byun, Kyung Bok Lee, Sun Seong Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Risk epithelial ovarian cancer 0301 basic medicine medicine.medical_specialty endocrine system diseases F-18 FDG PET/CT Standardized uptake value Carcinoma Ovarian Epithelial 03 medical and health sciences WAP Four-Disulfide Core Domain Protein 2 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Biomarkers Tumor medicine Humans Epithelial ovarian cancer Stage (cooking) Aged Retrospective Studies ROMA score Receiver operating characteristic business.industry Area under the curve SUVmax Retrospective cohort study General Medicine Middle Aged medicine.disease F 18 fdg pet ct female genital diseases and pregnancy complications 030104 developmental biology CA-125 Antigen 030220 oncology & carcinogenesis Female Radiology Radiopharmaceuticals Ovarian cancer business Algorithms Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Objective This study aimed to examine the diagnostic performance of F-18 fluorodeoxyglucose positron emission tomography with computed tomography (F-18 FDG PET/CT) compared with cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and risk of ovarian malignancy algorithm (ROMA) score to distinguish epithelial ovarian cancer from benign tumors. Methods A total of 46 patients with pelvic masses, who underwent F-18 FDG PET/CT, CA125, and HE4 before surgery between January 2015 and December 2018, were included in this retrospective study. The diagnostic performance of CA125, HE4, ROMA score, and maximum standardized uptake value (SUVmax) to differentiate epithelial ovarian cancer from benign pelvic tumors was examined by receiver operating characteristic curve analysis. Results Among the 46 patients, 28 were cases of ovarian cancers and 18 were of benign. The mean values of CA125, HE4, ROMA score, and SUVmax were significantly higher in the ovarian cancer group than the benign group. In early cancer stages (stages I and II), Area under the curve for SUVmax was significantly higher than CA125 and ROMA score (0.778 for CA125, 0.753 for HE4, 0.682 for ROMA score, and 0.922 for SUVmax). Conclusion SUVmax using F-18 FDG PET/CT showed a high diagnostic accuracy for differentiating epithelial ovarian cancer from benign pelvic tumors, including early stage ovarian cancer. F-18 FDG PET/CT can be a useful modality for the assessment of pelvic mass. . |
| Databáze: | OpenAIRE |
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