Oxidative stress and anti-oxidant status in diabetic rat liver: Effect of plant polyphenols
Autor: | Sadık Büyükbaş, Hakkı Gökbel, Muaz Belviranli, Nilsel Okudan |
---|---|
Rok vydání: | 2012 |
Předmět: |
Male
Xanthine Oxidase food.ingredient Physiology medicine.medical_treatment Intraperitoneal injection Pharmacology medicine.disease_cause Antioxidants Rats Sprague-Dawley Lipid peroxidation chemistry.chemical_compound food Malondialdehyde Physiology (medical) Diabetes mellitus Diabetes Mellitus medicine Animals Xanthine oxidase Nitrites Nitrates Grape Seed Extract Chemistry Polyphenols General Medicine medicine.disease Streptozotocin Rats Oxidative Stress Liver Biochemistry Grape seed extract Dietary Supplements Biomarkers Oxidative stress medicine.drug |
Zdroj: | Archives of Physiology and Biochemistry. 118:237-243 |
ISSN: | 1744-4160 1381-3455 |
DOI: | 10.3109/13813455.2012.702775 |
Popis: | Increased evidence in role of oxidative stress and grape seed extract (GSE) in diabetes and its complication led us to investigate the changes of oxidative stress and anti-oxidant defence in liver tissue of diabetic rats and possible effects of GSE. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Seven days after STZ injection four groups were formed: Control, GSE-supplemented control, diabetic and GSE-supplemented diabetic and GSE was given for 6 weeks. Malondialdehyde levels and xanthine oxidase activities were not different among the groups. However, nitric oxide (NO) levels were higher in diabetic and GSE supplemented groups compared with non-diabetic and non-supplemented groups, respectively. Total anti-oxidant activity (TAA) was lower in diabetic groups compared with their non-diabetic controls and it was not affected by GSE. In conclusion, GSE supplementation has limited protective effect in liver tissue of diabetic rats via affecting NO levels and was not affecting TAA. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |
načítá se...