R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infections
| Autor: | Célia Nogueira, António Meliço-Silvestre, Graça Rocha, Teresa Gonçalves, Rui Soares |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Blood/Heart Lymphatics HAART business.industry viruses Ear infection RNA Viral Protein R Case Report Case presentation medicine.disease AIDS/HIV-1 Microbiology Virology Asymptomatic Acquired immunodeficiency syndrome (AIDS) Vpr mutation Clinical support Immunology Medicine asymptomatic medicine.symptom business Viral load long-term non-progressor |
| Zdroj: | JMM Case Reports |
| ISSN: | 2053-3721 |
| Popis: | Introduction: Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV‐1) has been described as being involved in the progression of AIDS, and specific mutations are associated with long‐term non‐progressor patients. Case presentation: We describe the case of a child with repeated ear infections who was otherwise healthy. The patient, a 5‐year‐old boy, was HIV‐1 positive and the viral load at admission was 1 073 899 RNA copies ml−1 and 0 % CD4+ lymphocytes. A detailed study of the vpr gene sequence of the child revealed mutations leading to amino acid substitutions at positions 3 and 77. Conclusion: The case reported provides clinical support of previous findings that show that the R77Q and Q3R HIV‐1 Vpr variants are associated with patients with delayed disease progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|