Impact of Age and Cardiac Disease on Regional Left and Right Ventricular Myocardial Motion in Healthy Controls and Patients with Repaired Tetralogy of Fallot

Autor: Haben Berhane, Michael J. Rose, James C. Carr, Kenny Sidoryk, Cynthia K. Rigsby, Roberto Sarnari, Joshua D. Robinson, Ryan S. Dolan, Alexander Ruh, Michael Markl, Kai Lin, Arleen Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Cardiac function curve
Adult
Male
medicine.medical_specialty
Time Factors
Heart disease
Adolescent
Ventricular Dysfunction
Right
Diastole
Pilot Projects
030204 cardiovascular system & hematology
Article
Ventricular Function
Left
030218 nuclear medicine & medical imaging
Biventricular function
03 medical and health sciences
Ventricular Dysfunction
Left
Young Adult
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Cardiac Surgical Procedures
Child
Cardiac imaging
Tetralogy of Fallot
Aged
Reproducibility
business.industry
Age Factors
Infant
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Biomechanical Phenomena
Treatment Outcome
Case-Control Studies
Child
Preschool
Cardiology
Myocardial motion
Ventricular Function
Right
Feasibility Studies
Female
Cardiology and Cardiovascular Medicine
business
Zdroj: Int J Cardiovasc Imaging
Popis: The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61%, p
Databáze: OpenAIRE
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