Drimane Sesquiterpenoids from theAspergillus oryzaeQXPC-4
| Autor: | Hui Ming Ge, Ren-Xiang Tan, Chao-Jun Chen, Rui-Hua Jiao, Sha-sha Hu, Wen-Yong Zhu, Ren Ren |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Polycyclic Sesquiterpenes Strain (chemistry) biology Chemistry Liquid culture Stereochemistry Aspergillus oryzae Antineoplastic Agents Bioengineering General Chemistry General Medicine Crystallography X-Ray biology.organism_classification Biochemistry Cell culture Cell Line Tumor Neoplasms Humans Molecular Medicine Cytotoxicity Sesquiterpenes Molecular Biology Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Chemistry & Biodiversity. 12:371-379 |
| ISSN: | 1612-1872 |
| Popis: | Three new drimane sesquiterpenoids, astellolides C-E (1-3, resp.), four new drimane sesquiterpenoid p-hydroxybenzoates, astellolides F-I (4-7, resp.), together with two known compounds astellolides A and B (8 and 9, resp.), have been isolated from the liquid culture of Aspergillus oryzae (strain No. QXPC-4). Their structures were established by comprehensive analysis of spectroscopic data. The relative and absolute configurations were determined on the basis of NOESY and CD data, together with single-crystal X-ray diffraction analyses of compounds 1-3. The metabolites were evaluated for their cytotoxic activities, however, no compounds showed a significant cytotoxicity against the tested cell lines at a concentration of 20 μM. |
| Databáze: | OpenAIRE |
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