Safety and Efficacy of a Disposable Vaginal Device for Stress Urinary Incontinence
| Autor: | Peter Gaccione, Robert Shapiro, Omar Felipe Dueñas-Garcia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Pessary medicine.medical_specialty Urinary Incontinence Stress Urology Population Urinary incontinence Vaginal device Article Internal medicine Humans Medicine Disposable Equipment education Adverse effect Aged education.field_of_study business.industry Obstetrics and Gynecology Middle Aged Pessaries Self Care Treatment Outcome Vagina Population study Female Surgery medicine.symptom business Weight gain |
| Zdroj: | Female Pelvic Med Reconstr Surg |
| ISSN: | 2151-8378 |
| DOI: | 10.1097/spv.0000000000000861 |
| Popis: | OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of an over-the-counter device for the treatment of stress urinary incontinence (SUI) in females. METHODS: A multicenter, interventional, single-arm study involving 5 different sites was conducted including women diagnosed with symptomatic SUI using a self-inserted pessary device. A 1-week baseline period was followed by a 2-week period of wearing the device. The main outcome of our study was to determine if the device was able to reduce at least 50% the number of leakage events and pad weight. RESULTS: Across all study sites, 73 subjects were enrolled and 51 completed the study. Efficacy analyses were conducted on the modified intent-to-treat population (n = 48), whereas the safety analysis was conducted on all consented participants. The average pad weight gain was 0.9 g/h at baseline and 0.5 g/h during the treatment phase. The number of leakage episodes per day decreased from 2 at baseline to 0.9 during the treatment phase (P < 0.0001). Seventy-one percent of the study population experienced a more than 50% reduction in leakage volume, leakage episodes, or both. The quality of life scores improved from baseline to posttreatment phase by 4.35 points on average (P < 0.0001). A total of 40 adverse events were recorded, and only 4 subjects withdrew due to adverse events. CONCLUSIONS: The self-deployable pessary device evaluated in this study is an alternative option for women seeking an over-the-counter method to manage symptoms of SUI. Further studies are required to determine the long-term effects and compliance using the device. |
| Databáze: | OpenAIRE |
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