Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
| Autor: | Nasim Karim, Jahan Ara Hassan, Rabia Arshad, Muhammad Adnan Kanpurwala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Gross morphology Placenta Blood sugar 030209 endocrinology & metabolism Group A Group B 03 medical and health sciences 0302 clinical medicine Microscopic morphology Internal medicine medicine Fibrinoid necrosis Exercise Gestational diabetes 030219 obstetrics & reproductive medicine Chorangiosis business.industry General Medicine medicine.disease Metformin Diet medicine.anatomical_structure Endocrinology Original Article business medicine.drug |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X 1682-024X |
| Popis: | Objective: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). Methods: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level 130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology. Results: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant. Conclusion: Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|