Dissecting the Pre-Columbian genomic ancestry of Native Americans along the Andes-Amazonia divide
| Autor: | Patrizia Di Cosimo, Davide Gentilini, Tullia Di Corcia, Marco Sazzini, Zelda Alice Franceschi, Claudio Franceschi, Laura Gianvincenzo, Stefania Sarno, Elisabetta Cilli, Sara De Fanti, Taylor Jesus Dàvila Francia, Olga Rickards, Cristina Giuliani, Eugenio Bortolini, Antonio González-Martín, Cesar Sanchez Mellado, Davide Pettener, Guido Alberto Gnecchi-Ruscone, Donata Luiselli, Anna Maria Di Blasio, Alessio Boattini |
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| Přispěvatelé: | Gnecchi-Ruscone, Guido Alberto, Sarno, Stefania, De Fanti, Sara, Gianvincenzo, Laura, Giuliani, Cristina, Boattini, Alessio, Bortolini, Eugenio, Di Corcia, Tullia, Sanchez Mellado, Cesar, Dàvila Francia, Taylor Jesu, Gentilini, Davide, Di Blasio, Anna Maria, Di Cosimo, Patrizia, Cilli, Elisabetta, Gonzalez-Martin, Antonio, Franceschi, Claudio, Franceschi, Zelda Alice, Rickards, Olga, Sazzini, Marco, Luiselli, Donata, Pettener, Davide |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Gene Flow
0106 biological sciences population genomics Human Migration genome-wide SNPs Andes Biology Settore BIO/08 Polymorphism Single Nucleotide 010603 evolutionary biology 01 natural sciences Beringia Lineage (anthropology) Native American ancestry 03 medical and health sciences Amazonia Genetic drift Genetics Humans Molecular Biology Discoveries Ecology Evolution Behavior and Systematics 030304 developmental biology Principal Component Analysis 0303 health sciences Models Genetic Genome Human Amazon rainforest Human migration business.industry Indians South American Genetic Variation South America 15. Life on land Genética Phylogeography Evolución Haplotypes Evolutionary biology Genetic structure population genomics Native American ancestry genome-wide SNPs Andes Amazonia Gene pool business |
| Zdroj: | E-Prints Complutense. Archivo Institucional de la UCM instname Molecular Biology and Evolution E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid |
| Popis: | Extensive European and African admixture coupled with loss of Amerindian lineages makes the reconstruction of pre-Columbian history of Native Americans based on present-day genomes extremely challenging. Still open questions remain about the dispersals that occurred throughout the continent after the initial peopling from the Beringia, especially concerning the number and dynamics of diffusions into South America. Indeed, if environmental and historical factors contributed to shape distinct gene pools in the Andes and Amazonia, the origins of this East-West genetic structure and the extension of further interactions between populations residing along this divide are still not well understood. To this end, we generated new high-resolution genome-wide data for 229 individuals representative of one Central and ten South Amerindian ethnic groups from Mexico, Peru, Bolivia, and Argentina. Low levels of European and African admixture in the sampled individuals allowed the application of fine-scale haplotype-based methods and demographic modeling approaches. These analyses revealed highly specific Native American genetic ancestries and great intragroup homogeneity, along with limited traces of gene flow mainly from the Andes into Peruvian Amazonians. Substantial amount of genetic drift differentially experienced by the considered populations underlined distinct patterns of recent inbreeding or prolonged isolation. Overall, our results support the hypothesis that all non-Andean South Americans are compatible with descending from a common lineage, while we found low support for common Mesoamerican ancestors of both Andeans and other South American groups. These findings suggest extensive back-migrations into Central America from non-Andean sources or conceal distinct peopling events into the Southern Continent. |
| Databáze: | OpenAIRE |
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