DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview
| Autor: | Niels Herluf Paulsen, Fie Vojdeman, Stig Ejdrup Andersen, Troels K. Bergmann, Marianne Ewertz, Peter Plomgaard, Morten Rix Hansen, Peter Skov Esbech, Per Pfeiffer, Camilla Qvortrup, Per Damkier |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Paulsen, N H, Vojdeman, F, Andersen, S E, Bergmann, T K, Ewertz, M, Plomgaard, P, Hansen, M R, Esbech, P S, Pfeiffer, P, Qvortrup, C & Damkier, P 2022, ' DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview ', Basic and Clinical Pharmacology and Toxicology, vol. 131, no. 5, pp. 325-346 . https://doi.org/10.1111/bcpt.13782 |
| DOI: | 10.1111/bcpt.13782 |
| Popis: | Background: In clinical oncology, systemic 5-fluorouracil (5-FU) and its oral pro-drugs are used to treat a broad group of solid tumours. Patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency are at elevated risk of toxicity if treated with standard doses of 5-FU. DPYD genotyping and measurements of plasma uracil concentration (DPD phenotyping) can be applied as tests for DPD deficiency. In April 2020, the European Medicines Agency recommended pre-treatment DPD testing to reduce the risk of 5-FU-related toxicity. Objectives: The objective of this study is to present the current evidence for DPD testing in routine oncological practice. Methods: Two systematic literature searches were performed following the PRISMA guidelines. We identified studies examining the possible benefit of DPYD genotyping or DPD phenotyping on the toxicity risk. Findings: Nine and 12 studies met the criteria for using DPYD genotyping and DPD phenotyping, respectively. Conclusions: The evidence supporting either DPYD genotyping or DPD phenotyping as pre-treatment tests to reduce 5-FU toxicity is poor. Further evidence is still needed to fully understand and guide clinicians to dose by DPD activity. |
| Databáze: | OpenAIRE |
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