Clinical outcomes and prognostic factors in patients with no less than three distant organ system metastases from differentiated thyroid carcinoma
| Autor: | Jian-Wen Sun, Xiao-Yue Chen, Xin-Yun Zhang, Jin-Hua Zhao, Yang Wang, Zhong-Ling Qiu, Quan-Yong Luo |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Lung Neoplasms Multivariate analysis Endocrinology Diabetes and Metabolism Bone Neoplasms 030209 endocrinology & metabolism Adenocarcinoma Iodine Radioisotopes Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Overall survival Humans Medicine Avidity In patient Thyroid Neoplasms Organ system Aged Retrospective Studies Aged 80 and over business.industry Proportional hazards model Middle Aged Prognosis medicine.disease Survival Rate Treatment Outcome 030220 oncology & carcinogenesis Female business |
| Zdroj: | Endocrine. 66:254-265 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-019-01999-6 |
| Popis: | For patients with differentiated thyroid carcinoma (DTC), distant metastases are commonly identified in the lungs and bones. However, they are relatively rare in other distant organs, such as the liver, kidneys, or brain. The aim of the current study was to describe the clinical outcomes and evaluate the prognostic factors of patients with no less than three different distant organ system metastases from DTC. This study retrospectively identified 717 patients diagnosed with DTC with distant metastases between January 2005 and December 2017. Patient response to radioactive iodine (RAI) therapy was monitored by changes in serum thyroglobulin levels and imaging changes. Five-year and 10-year overall survival (OS) rates were calculated by the Kaplan–Meier methods and Cox proportional hazards. Among the 717 participants, 37 (5.16%) patients had no less than three different distant organ system metastases from DTC. Five-year and 10-year OS were 45.9% and 37.8% in patients with three or more distant organ system metastases while 74.5% and 64.9% in individuals with one or two distant organ system metastases, respectively. RAI avidity and RAIR-DTC were main independent prognostic factors influencing the clinical outcomes for both groups of patients. The presence of 3 or more different distant organ system metastases was the only independent prognostic factors for 10-year OS by multivariate analysis. Patients with no less than three distant organ system metastases from DTC had poor prognosis. RAI avidity and RAIR-DTC were main factors influencing overall survival for patients with distant metastases from DTC in both groups. |
| Databáze: | OpenAIRE |
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