Turmeric based oral rinse 'HTOR-091516' ameliorates experimental oral mucositis
| Autor: | Rangesh Paramesh, Sandeep Varma, Shruthi Manjunath Hegde, Mohammed Azeemuddin, Dilip Niranjan, Onkaramurthy Mallappa, Mohamed Rafiq, Ashok Basti Krishnaiah, S. D. Anturlikar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
biology
Epidermis (botany) medicine.drug_class business.industry General Medicine Pharmacology biology.organism_classification medicine.disease Anti-inflammatory Ayurvedic formulation medicine Mucositis Bioassay Tumor necrosis factor alpha Original Article 5-fluorouracil Viability assay Curcuma business Triphala tumor necrosis factor-alpha anti-inflammatory oral mucositis |
| Zdroj: | Ayu |
| ISSN: | 0974-8520 |
| Popis: | Background: Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation “HTOR-091516” containing Curcuma longa, Triphala and honey were evaluated for the treatment of OM. Aim: The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats. Materials and Methods: The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples. Results: The in vitro safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level. Conclusion: The present data indicate that HTOR-091516 is effective in the treatment of OM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|