Imidazolium-Based Lipid Analogues and Their Interaction with Phosphatidylcholine Membranes
| Autor: | Djurre H. de Jong, Andreas Rühling, Hans-Joachim Galla, Frank Glorius, Stephanie Wulff, Andreas Heuer, Karina Shimizu, Da Wang, Volker Lesch |
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| Rok vydání: | 2016 |
| Předmět: |
1
2-Dipalmitoylphosphatidylcholine Surface Properties Lipid Bilayers Static Electricity 02 engineering and technology Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences chemistry.chemical_compound Phosphatidylcholine Monolayer Electrochemistry Membrane fluidity Organic chemistry Computer Simulation General Materials Science Lipid bilayer phase behavior Lipid bilayer Spectroscopy Liposome Calorimetry Differential Scanning Chemistry Bilayer Imidazoles technology industry and agriculture Hydrogen Bonding Membranes Artificial Surfaces and Interfaces 021001 nanoscience & nanotechnology Condensed Matter Physics Lipids 0104 chemical sciences Kinetics Membrane Microscopy Fluorescence Chemical engineering Liposomes Phosphatidylcholines Thermodynamics lipids (amino acids peptides and proteins) 0210 nano-technology |
| Zdroj: | Langmuir. 32:12579-12592 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.6b02496 |
| Popis: | 4,5-Dialkylated imidazolium lipid salts are a new class of lipid analogues showing distinct biological activities. The potential effects of the imidazolium lipids on artificial lipid membranes and the corresponding membrane interactions was analyzed. Therefore, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was employed to create an established lipid monolayer model and a bilayer membrane. Mixed monolayers of DPPC and 4,5-dialkylimidazolium lipids differing by their alkyl chain length (C7, C11, and C15) were characterized by surface pressure–area (π–A) isotherms using a Wilhelmy film balance in combination with epifluorescence microscopy. Monolayer hysteresis for binary mixtures was examined by recording triplicate consecutive compression–expansion cycles. The lipid miscibility and membrane stability of DPPC/imidazolium lipids were subsequently evaluated by the excess mean molecular area (ΔAex) and the excess Gibbs free energy (ΔGex) of mixing. Furthermore, the thermotropic behavior of mixed liposomes... |
| Databáze: | OpenAIRE |
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