Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway
| Autor: | Zhen Li, Ye-Gang Ma, Yongyu Liu, Chengliang Yang, Yi Ren, De-Gui Liu, Xiaobai Liu, Yao Li, Yixue Xue |
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| Rok vydání: | 2012 |
| Předmět: |
Lung Neoplasms
Angiogenesis Tumor Physiology Cancer Treatment lcsh:Medicine medicine.disease_cause Lung and Intrathoracic Tumors Metastasis chemistry.chemical_compound Small Cell Lung Cancer Cell Movement Molecular Cell Biology Basic Cancer Research lcsh:Science Multidisciplinary Neovascularization Pathologic Cell Cycle Cell migration Cell cycle Cell biology Oncology Medicine RNA Interference Signal Transduction Research Article STAT3 Transcription Factor Drugs and Devices Curcumin Antineoplastic Agents Biology Signaling Pathways Complementary and Alternative Medicine Cell Line Tumor medicine Humans Cyclin B1 Cell Proliferation Janus Kinases Cell growth Interleukin-6 lcsh:R Cancers and Neoplasms Small Cell Lung Carcinoma Matrix Metalloproteinases chemistry Ethnopharmacology Cancer research STAT protein lcsh:Q Janus kinase Carcinogenesis |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 5, p e37960 (2012) |
| ISSN: | 1932-6203 |
| Popis: | Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about its anti-tumor mechanism in small cell lung cancer (SCLC). In this study, we found that curcumin can inhibit SCLC cell proliferation, cell cycle, migration, invasion and angiogenesis through suppression of the STAT3. SCLC cells were treated with curcumin (15 µmol/L) and the results showed that curcumin was effective in inhibiting STAT3 phosphorylation to downregulate of an array of STAT3 downstream targets ,which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion. Curcumin also suppressed the expression of proliferative proteins (Survivin, Bcl-X(L) and Cyclin B1), and invasive proteins (VEGF, MMP-2, MMP-7 and ICAM-1). Knockdown of STAT3 expression by siRNA was able to induce anti-invasive effects in vitro. In contrast, activation of STAT3 upstream of interleukin 6 (IL-6) leads to the increased cell proliferation ,cell survival, angiogenesis, invasion, migration and tumor growth. Our findings illustrate the biologic significance of IL-6/JAK/STAT3 signaling in SCLC progression and provide novel evidence that the pathway may be a new potential target for therapy of SCLC. It was concluded that curcumin is a potent agent in the inhibition of STAT3 with favorable pharmacological activity,and curcumin may have translational potential as an effective cancer therapeutic or preventive agent for SCLC. |
| Databáze: | OpenAIRE |
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