Effects of schizophrenomimetics on the expression of the CCN1 (CYR 61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat
| Autor: | Sumikazu Ishii, Toru Nishikawa, Takashi Ito, Naoki Yamamoto, Shuichi Hiraoka, Akeo Kurumaji, Atsushi Kashiwa, Yasukazu Kuroda, Asami Umino |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Down-Regulation Phencyclidine Neocortex Biology Receptors N-Methyl-D-Aspartate Immediate-Early Proteins Mice Internal medicine Extracellular medicine Animals Pharmacology (medical) Rats Wistar Gene Oligonucleotide Array Sequence Analysis Pharmacology Reverse Transcriptase Polymerase Chain Reaction Matricellular protein DNA Methamphetamine Blotting Northern Rats Up-Regulation Mice Inbred C57BL Dizocilpine Psychiatry and Mental health medicine.anatomical_structure Endocrinology Hallucinogens Schizophrenia Systemic administration Intercellular Signaling Peptides and Proteins RNA Schizophrenic Psychology Excitatory Amino Acid Antagonists Cysteine-Rich Protein 61 medicine.drug |
| Zdroj: | The International Journal of Neuropsychopharmacology. 10 |
| ISSN: | 1469-5111 1461-1457 |
| DOI: | 10.1017/s1461145707007882 |
| Popis: | The acute systemic administration of a schizophrenomimetic phencyclidine [5 or 10 mg/kg, subcutaneously (s.c.)] markedly up-regulated the neocortical expression of the CCN1 gene encoding a secreted extracellular matrix-associated protein at postnatal day 56, but not at postnatal day 8, after 60 min in the mouse and rat. The development-dependent nature of the up-regulation between postnatal days 8 and 56 seems to be similar to that of the adult type phencyclidine-induced abnormal behaviours, which have been considered to be models of schizophrenic symptoms. In the young adult rat, 5, 10, and 20 mg/kg phencyclidine (given s.c.) induced an increase in the CCN1 gene transcripts in a dose-related and bell-shaped manner with a maximum at the dose of 10 mg/kg, 60 min post-injection. Other schizophrenomimetics, dizocilpine (1 mg/kg) and methamphetamine (4.8 mg/kg), also caused a prominent up-regulation of the neocortical expression of the CCN1 gene in adult rats. These results indicate that the CCN1 gene or protein could be implicated in a molecular cascade associated with the age-dependent onset of schizophrenia that usually occurs after puberty. |
| Databáze: | OpenAIRE |
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