Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium

Autor:	Sandra Díaz Del Moral, Silvia Barrena, Ramón Muñoz-Chápuli, Rita Carmona
Rok vydání:	2020
Předmět:	0301 basic medicine Aging Lineage (genetic) endothelium Endothelium circulating endothelial progenitors Biology Kidney Article Mesoderm Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Cell Lineage Progenitor cell lcsh:QH301-705.5 Endocardium coronary vessels Fetus GATA4 Myocardium Endothelial Cells General Medicine Embryo Mammalian Hematopoietic Stem Cells Embryonic stem cell GATA4 Transcription Factor Cell biology Haematopoiesis 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Animals Newborn cardiovascular system vascular growth 030217 neurology & neurosurgery
Zdroj:	Cells Volume 9 Issue 5 Cells, Vol 9, Iss 1257, p 1257 (2020)
ISSN:	2073-4409
DOI:	10.3390/cells9051257
Popis:	Different sources have been claimed for the embryonic origin of the coronary endothelium. Recently, the potential of circulating cells as progenitors of the cardiac endothelium has also been suggested. In a previous study we have shown that circulating progenitors are recruited by the embryonic endocardium and incorporated into the coronary vessels. These progenitors derive from a mesodermal lineage characterized by the expression of Gata4 under control of the enhancer G2. Herein, we aim to trace this specific lineage throughout postnatal stages. We have found that more than 50% of the adult cardiac endothelium derives from the G2-GATA4 lineage. This percentage increases from embryos to adults probably due to differential proliferation and postnatal recruitment of circulating endothelial progenitors. In fact, injection of fetal liver or placental cells in the blood stream of neonates leads to incorporation of G2-GATA4 lineage cells to the coronary endothelium. On the other hand, labeling of the hematopoietic lineage by the stage E7.5 also resulted in positive coronary endothelial cells from both, embryos and adults. Our results suggest that early hematopoietic progenitors recruited by the embryonic ventricular endocardium can become the predominant source of definitive endothelium during the vascularization of the heart.
Databáze:	OpenAIRE
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