Stimulation of dopamine biosynthesis in cultured PC 12 phaeochromocytoma cells by the coenzyme nicotinamide adeninedinucleotide (NADH)
| Autor: | J. G. D. Birkmayer, K. Vrecko, J. Krainz |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Tyrosine 3-Monooxygenase
Dopamine PC12 Cells Cofactor chemistry.chemical_compound medicine Animals Aromatic Amino Acid Decarboxylase Inhibitors Biological Psychiatry chemistry.chemical_classification Nicotinamide Tyrosine hydroxylase biology General Neuroscience NAD Stimulation Chemical Rats Psychiatry and Mental health Hydrazines Enzyme Neurology Biochemistry chemistry Cell culture Catecholamine biology.protein Neurology (clinical) medicine.drug |
| Zdroj: | Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 5:147-156 |
| ISSN: | 1435-1463 0936-3076 |
| Popis: | The activity of the tyrosine hydroxylase, the enzyme which is diminished in the brains of Parkinson patients, has been measured in cultured PC 12 rat phaeochromocytoma cells. In the same way dopamine content in the medium after incubating these cells with or without NADH was assayed. The experiment shows that NADH is able to increase the activity of the tyrosine hydroxylase and dopamine - production in PC 12 cells up to 6 times. The results provide evidence that NADH is able to stimulate dopamine - biosynthesis directly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink