Repurposing an Antiviral Drug against SARS‐CoV‐2 Main Protease

Autor:	Kalyaneswar Mandal, Arighna Sarkar
Rok vydání:	2021
Předmět:	Antiviral Drugs 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Peptidomimetic medicine.drug_class medicine.medical_treatment Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Biology Crystallography X-Ray Antiviral Agents Catalysis Chlorocebus aethiops medicine Animals Protease Inhibitors drug screening Vero Cells Coronavirus 3C Proteases Repurposing Highlight Protease Molecular Structure SARS-CoV-2 allosteric inhibitors Drug Repositioning General Medicine General Chemistry Virology Highlights Drug repositioning X-ray crystallographic screening Antiviral drug Allosteric Site
Zdroj:	Angewandte Chemie (International Ed. in English)
ISSN:	1521-3773 1433-7851
Popis:	This article highlights recent pioneering work by Gunther et†al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (Mpro ). The antiviral activity of the most potent drugs is discussed along with their binding mode to Mpro as observed through X-ray crystallographic screening.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3076e7938eb117ff97f2fc620e19e68 https://doi.org/10.1002/anie.202107481 Zobrazit plný text záznamu Plný text