Lower Extremity Motor Function and Disability in Mild Cognitive Impairment

Autor:	Neelum T. Aggarwal, Zoe Arvanitakis, Aron S. Buchman, Yuxiao Tang, Robert S. Wilson, Jeremiah F. Kelly, Patricia A. Boyle, David A. Bennett
Rok vydání:	2007
Předmět:	Male Aging medicine.medical_specialty Statistics as Topic Neurological disorder Neuropsychological Tests behavioral disciplines and activities Disability Evaluation Arts and Humanities (miscellaneous) Isometric Contraction Activities of Daily Living mental disorders medicine Postural Balance Humans Dementia Muscle Strength Gait General Psychology Aged Balance (ability) Memory and aging Aged 80 and over Neurologic Examination Vascular disease Dementia Vascular Cognitive disorder Peripheral Nervous System Diseases Middle Aged medicine.disease Lower Extremity Cardiovascular Diseases Physical therapy Female Geriatrics and Gerontology Cognition Disorders Mental Status Schedule Psychology human activities
Zdroj:	Experimental Aging Research. 33:355-371
ISSN:	1096-4657 0361-073X
DOI:	10.1080/03610730701319210
Popis:	Recent findings suggest that lower extremity motor dysfunction may be a feature of mild cognitive impairment (MCI), but little is known about the nature and significance of lower extremity motor dysfunction in MCI. The aim of this study was to examine the extent to which MCI is associated with impaired gait, balance, and strength and to examine the relation of lower extremity function to disability among persons with MCI in the Rush Memory and Aging Project, a clinical-pathologic study of common chronic conditions of old age. In a series of analyses adjusted for age, sex, and education, individuals with MCI exhibited more impaired gait and balance than individuals without cognitive impairment. Because vascular factors can contribute to lower extremity motor dysfunction, the authors repeated the initial analyses including terms for vascular risk factors and vascular disease, and the associations between MCI and lower extremity motor dysfunction persisted. Moreover, among those with MCI, impairments in gait and balance were associated with an increased likelihood of disability. These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study.
Databáze:	OpenAIRE
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