Contributions of aortic pulse wave velocity and backward wave pressure to variations in left ventricular mass are independent of each other
| Autor: | Angela J. Woodiwiss, Imraan Ballim, Hamza Bello, Pinhas Sareli, Carlos D. Libhaber, Gavin R. Norton |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart Ventricles Hemodynamics Black People Blood Pressure 030204 cardiovascular system & hematology Pulse Wave Analysis Left ventricular hypertrophy 03 medical and health sciences 0302 clinical medicine Sex Factors Internal medicine Internal Medicine Medicine Humans Arterial Pressure cardiovascular diseases 030212 general & internal medicine Aortic Pulse Pressure Pulse wave velocity Aorta business.industry Confounding Blood Pressure Determination Organ Size Middle Aged medicine.disease Pulse pressure Blood pressure Echocardiography cardiovascular system Cardiology Aortic stiffness Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Journal of the American Society of Hypertension : JASH. 11(5) |
| ISSN: | 1878-7436 |
| Popis: | Aortic pulse wave velocity (PWV) and backward waves, as determined from wave separation analysis, predict cardiovascular events beyond brachial blood pressure. However, the extent to which these aortic hemodynamic variables contribute independent of each other is uncertain. In 749 randomly selected participants of African ancestry, we therefore assessed the extent to which relationships between aortic PWV or backward wave pressures (Pb) (and hence central aortic pulse pressure [PPc]) and left ventricular mass index (LVMI) occur independent of each other. Aortic PWV, PPc, forward wave pressure (Pf), and Pb were determined using radial applanation tonometry and SphygmoCor software and LVMI using echocardiography; 44.5% of participants had an increased left ventricular mass indexed to height1.7. With adjustments for age, brachial systolic blood pressure or PP, and additional confounders, PPc and Pb, but not Pf, were independently related to LVMI and left ventricular hypertrophy (LVH) in both men and women. However, PWV was independently associated with LVMI in women (partial r = 0.16, P < .001), but not in men (partial r = 0.03), and PWV was independently associated with LVH in women (P < .05), but not in men (P = .07). With PWV and Pb included in the same multivariate regression models, PWV (partial r = 0.14, P < .005) and Pb (partial r = 0.10, P < .05) contributed to a similar extent to variations in LVMI in women. In addition, with PWV and Pb included in the same multivariate regression models, PWV (P < .05) and Pb (P < .02) contributed to LVH in women. In conclusion, aortic PWV and Pb (and hence pulse pressure) although both associated with LVMI and LVH produce effects which are independent of each other. |
| Databáze: | OpenAIRE |
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