Protective effect ofZingiber officinaleextract on rat testis after cyclophosphamide treatment
| Autor: | Alireza Moravveji, S. M. Hosseini, Aliakbar Taherian, Hossein Nikzad, Forouzan Mohammadi, Abolfazl Azami-Tameh, Mohsen Taghizadeh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Antioxidant Cyclophosphamide Urology medicine.medical_treatment Ginger Extract Ginger Pharmacology Antioxidants chemistry.chemical_compound Endocrinology Blood serum Malondialdehyde Testis medicine Animals Testosterone Rats Wistar Antineoplastic Agents Alkylating Chemotherapy Sertoli Cells Sperm Count Plant Extracts business.industry General Medicine Rats chemistry Zingiber officinale Reactive Oxygen Species business medicine.drug |
| Zdroj: | Andrologia. 46:680-686 |
| ISSN: | 0303-4569 |
| Popis: | Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide-treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg(-1) BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants. |
| Databáze: | OpenAIRE |
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