Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug
Autor: | Carolina Maldonado Galdeano, María José Martínez Monteros, Ricardo Weill, Maria Florencia Balcells, Gabriela Perdigón, Silvia Inés Cazorla, Juan A. De Paula |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Indomethacin Cell Administration Oral medicine.disease_cause T-Lymphocytes Regulatory law.invention purl.org/becyt/ford/1 [https] Probiotic 0302 clinical medicine law Large intestine Mice Inbred BALB C Multidisciplinary Anti-Inflammatory Agents Non-Steroidal Antimicrobial Interleukin-10 Intestines medicine.anatomical_structure Mucosal immunology Medicine 030211 gastroenterology & hepatology Goblet Cells medicine.symptom PANETH CELLS INTESTINAL INFLAMMATION Science Inflammation Microbiology Article 03 medical and health sciences INTESTINAL MICROBIOTA medicine Animals Secretion PROBIOTIC LACTOBACILLI purl.org/becyt/ford/1.6 [https] business.industry Probiotics Inflammatory Bowel Diseases Small intestine Gastrointestinal Microbiome Disease Models Animal Lactobacillus Oxidative Stress 030104 developmental biology Dietary Supplements Immunology Intestinal diseases business Oxidative stress |
Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) Scientific Reports |
Popis: | Damage to the small intestine caused by non-steroidal anti-inflammatory drugs (NSAIDs) occurs more frequently than in the upper gastrointestinal tract, is more difficult to diagnose and no effective treatments exist. Hence, we investigated whether probiotics can control the onset of this severe condition in a murine model of intestinal inflammation induced by the NSAID, indomethacin. Probiotic supplementation to mice reduce the body weight loss, anemia, shortening of the small intestine, cell infiltration into the intestinal tissue and the loss of Paneth and Goblet cells associated with intestinal inflammation. Furthermore, a high antimicrobial activity in the intestinal fluids of mice fed with probiotics compared to animals on a conventional diet was elicited against several pathogens. Interestingly, probiotics dampened the oxidative stress and several local and systemic markers of an inflammatory process, as well as increased the secretion of IL-10 by regulatory T cells. Even more importantly, probiotics induced important changes in the large intestine microbiota characterized by an increase in anaerobes and lactobacilli, and a significant decrease in total enterobacteria. We conclude that oral probiotic supplementation in NSAID-induced inflammation increases intestinal antimicrobial activity and reinforces the intestinal epithelial barrier in order to avoid pathogens and commensal invasion and maintain intestinal homeostasis. Fil: Martínez Monteros, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Balcells, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Weill, Ricardo. Universidad Isalud; Argentina Fil: De Paula, Juan Andrés. Hospital Italiano; Argentina Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Cazorla, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina |
Databáze: | OpenAIRE |
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