Update of thermotolerant genes essential for survival at a critical high temperature in Escherichia coli
| Autor: | Mamoru Yamada, Hirotada Mori, Masayuki Murata, Hiroko Fujimoto, Tomoyuki Kosaka, Ayana Ishii, Kaori Nishimura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Metabolic Processes Hot Temperature Cell division Membrane Protein Complexes Cell Membranes lcsh:Medicine medicine.disease_cause Antiport Proteins Biochemistry Oxidative Phosphorylation chemistry.chemical_compound lcsh:Science Genetics Multidisciplinary Adaptation Physiological Nucleic acids Transfer RNA Cellular Structures and Organelles Bacterial outer membrane Research Article TRNA modification DNA repair Biology Biosynthesis 03 medical and health sciences medicine Escherichia coli Non-coding RNA Gene 030102 biochemistry & molecular biology Genetic Complementation Test lcsh:R Biology and Life Sciences Membrane Proteins Proteins Protein Complexes Cell Biology Intracellular Membranes DNA Outer Membrane Proteins 030104 developmental biology Metabolism chemistry Genes Bacterial RNA lcsh:Q |
| Zdroj: | PLoS ONE, Vol 13, Iss 2, p e0189487 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Previous screening of a single-gene knockout library consisting of 3,908 disrupted-mutant strains allowed us to identify 51 thermotolerant genes that are essential for survival at a critical high temperature (CHT) in Escherichia coli [Murata M, Fujimoto H, Nishimura K, Charoensuk K, Nagamitsu H, Raina S, Kosaka T, Oshima T, Ogasawara N, Yamada M (2011) PLoS ONE 6: e20063]. In this study, we identified another 21 thermotolerant genes. E. coli thus has 72 thermotolerant genes in total. The genes are classified into 8 groups: genes for energy metabolism, outer membrane organization, DNA double-strand break repair, tRNA modification, protein quality control, translation control, cell division and transporters. This classification and physiological analysis indicate the existence of fundamental strategies for survival at a CHT, which seems to exclude most of the heat shock responses. |
| Databáze: | OpenAIRE |
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