Current therapies for actinic keratosis
| Autor: | Anna Moret, Roberta Giuffrida, Iris Zalaudek, Nicola di Meo, Claudio Conforti, Paola Corneli, Giovanni Magaton Rizzi, Eleonora Farinazzo, Caterina Dianzani |
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| Přispěvatelé: | Dianzani, C., Conforti, C., Giuffrida, R., Corneli, P., di Meo, N., Farinazzo, E., Moret, A., Magaton Rizzi, G., Zalaudek, I. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
actinic keratosi
medicine.medical_specialty Diclofenac Skin Neoplasms Keratosis medicine.medical_treatment actinic keratosis treatment Aftercare Photodynamic therapy Cryotherapy Imiquimod Dermoscopy Dermatology Curettage 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Chemexfoliation Protective Clothing medicine Carcinoma Humans Skin business.industry Actinic keratosis medicine.disease Keratosis Actinic Photochemotherapy 030220 oncology & carcinogenesis Practice Guidelines as Topic Carcinoma Squamous Cell Disease Progression Sunlight Fluorouracil Laser Therapy business Sunscreening Agents medicine.drug |
| Popis: | Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reason, all AK should be treated, and clinical follow-up is recommended. The aims of treatment are: (i) to clinically eradicate evident and subclinical lesions, (ii) to prevent their evolution into SCC, and (iii) to reduce the number of relapses. Among available treatments, it is possible to distinguish lesion-directed therapies and field-directed therapies. Lesion-directed treatments include: (i) cryotherapy; (ii) laser therapy; (iii) surgery; and (iv) curettage. Whereas, field-directed treatments are: (i) 5-fluorouracil (5-FU); (ii) diclofenac 3% gel; (iii) chemical peeling; (iv) imiquimod; and (v) photodynamic therapy (PDT). Prevention plays an important role in the treatment of AKs, and it is based on the continuous use of sunscreen and protective clothing. This review shows different types of available treatments and describes the characteristics and benefits of each medication, underlining the best choice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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