Odor coding in the mammalian olfactory epithelium
| Autor: | Diogo Manoel, Rafaella G. Naressi, Smija M. Kurian, Ann-Sophie Barwich, Luis R. Saraiva, Bettina Malnic |
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| Rok vydání: | 2021 |
| Předmět: |
Histology
Sensory system Olfaction Review Biology RECEPTORES Olfactory Receptor Neurons Pathology and Forensic Medicine Olfactory mucosa medicine Animals Combinatorial code Mammals Mechanism (biology) musculoskeletal neural and ocular physiology Odor coding Antagonist Cell Biology Smell medicine.anatomical_structure Odorant Odor Odorants Neuroscience Olfactory epithelium psychological phenomena and processes Coding (social sciences) Receptor |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Cell and Tissue Research |
| Popis: | Noses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating the olfactory mucosa. Different odorants, or different concentrations of the same odorant, activate unique ensembles of ORs. This mechanism of combinatorial receptor coding provided a possible explanation as to why different odorants are perceived as having distinct odors. Aided by new technologies, several recent studies have found that antagonist interactions also play an important role in the formation of the combinatorial receptor code. These findings mark the start of a new era in the study of odorant-receptor interactions and add a new level of complexity to odor coding in mammals. |
| Databáze: | OpenAIRE |
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