The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression

Autor: Yoshie Shimotoyodome, Akira Hachiya, Yuki Miyauchi, Takashi Kitahara, Yusuke Shibuya, Taketoshi Fujimori, Shinya Kasamatsu, Kazuhiko Higuchi, Akiyo Kameyama, Atsushi Ohuchi
Rok vydání: 2014
Předmět:
Zdroj: Journal of Natural Medicines
ISSN: 1861-0293
1340-3443
Popis: The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring melanocytes via their Kit receptors. In order to identify effective skin-lightening materials, we screened botanical extracts to determine their abilities to diminish Kit expression in melanocytes. A Platycodon root extract was consequently found to have a remarkable inhibitory activity on Kit expression. When the extract was applied to three-dimensional human skin substitutes in vitro and to human skin in vivo after UVB irradiation, their pigmentation was significantly reduced, confirming the substantial contribution of the suppression of SCF/Kit signaling to preventing or inhibiting melanin synthesis. These data demonstrate that a Platycodon root extract is a promising material for a skin-lightening product to improve pigmentation-related diseases.
Databáze: OpenAIRE
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