Histotopography of α-Gustdusin- and T2R3-Expressing Lymphocytes in Mouse Spleen
| Autor: | V. G. Sergeyev, V. M. Chychkov, D. B. Nikityuk, I. A. Cherenkov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
Male 0301 basic medicine endocrine system Protein subunit Spleen General Biochemistry Genetics and Molecular Biology CD19 Receptors G-Protein-Coupled Mice 03 medical and health sciences 0302 clinical medicine Immune system stomatognathic system medicine Animals Tissue Distribution Lymphocytes Transducin Lymphatic Vessels Inflammation biology Bacterial polysaccharide General Medicine Gustducin Immunohistochemistry Molecular biology 030104 developmental biology medicine.anatomical_structure biology.protein 030217 neurology & neurosurgery Periarteriolar lymphoid sheaths Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 167:801-804 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04626-6 |
| Popis: | Histotopography of lymphocytes expressing bitter taste receptors of T2R family and α-gustducin (receptor-associated subunit of the G-protein complex) in mouse spleen in the norm and in 48 h after intraperitoneal administration of LPS was studied by the immunohistochemical method. Two populations of immunopositive lymphocytes expressing the above proteins were detected in the spleen; they were located in the marginal zones of lymphoid follicles and periarteriolar lymphoid sheaths. In most α-gustducin-positive lymphocytes, co-expression of α-gustducin and CD19 (B-cell marker) was found. Intraperitoneal administration of LPS significantly increased the number of gustducinergic lymphocytes in periarteriolar lymphoid sheaths. We hypothesize that spleen lymphocytes with gustducin signaling are involved in T-dependent immune response to the blood bacterial polysaccharides. |
| Databáze: | OpenAIRE |
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