Iron deficiency anaemia in hospitalised patients: value of various laboratory parameters Differentiation between IDA and ACD
| Autor: | A. van Tellingen, M.L.K Kooi, J.C Kuenen, W de Kieviet, W.L.E Vasmel, H van Tinteren |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia Transferrin receptor Gastroenterology chemistry.chemical_compound Surveys and Questionnaires hemic and lymphatic diseases Internal medicine Internal Medicine medicine Humans Prospective Studies Aged Aged 80 and over chemistry.chemical_classification Analysis of Variance Univariate analysis Anemia Iron-Deficiency biology business.industry Zinc protoporphyrin Iron deficiency Middle Aged medicine.disease Hospitalization Ferritin chemistry Iron-deficiency anemia Transferrin Immunology biology.protein Female business Biomarkers |
| Zdroj: | The Netherlands Journal of Medicine. 59:270-279 |
| ISSN: | 0300-2977 |
| DOI: | 10.1016/s0300-2977(01)00169-3 |
| Popis: | for the diagnostic evaluation of microcytic or normocytic anaemia in a heterogeneous group of patients, the value of newer parameters, such as zinc protoporphyrin (ZPP), plasma transferrin receptor (PtrfR) and PtrfR/ferritin ratio is not clear. We have performed a prospective study to determine the predictive value of these parameters and ferritin, for diagnosing iron deficiency anaemia (IDA).sixty-two patients with Hb8.2 (men) or7.0 (women) and mean cell volume (MCV)96 fl were included. Exclusion criteria were: known haematological disease, pregnancy, bone marrow suppression or iron therapy within the previous 7 days. Bone marrow examination was used as a golden standard to discriminate between IDA and non-IDA.twenty-four patients had depleted iron stores. We found that the reticulocyte response on iron supplementation correlated well with the iron-status of the bone marrow. Univariate analysis showed that ferritin, PtrfR/ferritin ratio, ZPP and PtrfR have significant predictive values for differentiating IDA from non-IDA. Interestingly, multivariate analysis revealed that ferritin was the only significant, independent predictor of IDA, with a cut-off point of 32 microg/l (sensitivity 79.2%, specificity 96.9%).the low sensitivity and specificity of ZPP, PtrfR and PtrfR/ferritin ratio render them insufficient to be used as a single 'best' test for the identification IDA in a non-selected group of anaemic patients and do not even add to the prediction if the value of ferritin is known. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|