Decreased peripheral blood memory B cells are associated with the presence of interstitial lung disease in rheumatoid arthritis: a case-control study
| Autor: | Shoko Tateishi, Hirofumi Shoda, Hiroaki Harada, Toshiaki Shimizu, Yasuo Nagafuchi, Norio Hanata, Kazuhiko Yamamoto, Shuji Sumitomo, Haruka Tsuchiya, Yumi Tsuchida, Keishi Fujio, Hiroko Kanda |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Naive B cell B-Lymphocyte Subsets Immunologic Tests Flow cytometry Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Japan Rheumatology medicine Humans 030212 general & internal medicine Lung 030203 arthritis & rheumatology B-Lymphocytes medicine.diagnostic_test business.industry Case-control study Interstitial lung disease medicine.disease Peripheral blood Case-Control Studies Rheumatoid arthritis Immunology Prednisolone Female Lung Diseases Interstitial Tomography X-Ray Computed business Immunologic Memory medicine.drug |
| Zdroj: | Modern Rheumatology. 31:127-132 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.1080/14397595.2020.1719596 |
| Popis: | Objectives: Interstitial lung disease sometimes occurs in rheumatoid arthritis patients. Although the underlying immunological mechanisms responsible for interstitial lung disease associated with rheumatoid arthritis have not yet been clarified, some reports have suggested possible roles of B cells. To examine the role of B-cell subsets in interstitial lung disease in rheumatoid arthritis patients, we analyzed peripheral blood B-cell subsets.Methods: We analyzed the frequencies of the peripheral blood B-cell subsets by flow cytometry in rheumatoid arthritis patients with and without interstitial lung disease (n = 16 and 81, respectively) and in healthy donors (n = 110) by high-resolution computed tomography.Results: Compared with healthy donors, rheumatoid arthritis patients showed statistically higher frequencies of naive B cells and lower frequencies of memory B cells. Moreover, the frequencies of memory B cells were lower in rheumatoid arthritis patients with interstitial lung disease than in those without. Multivariate analysis showed that the frequency of memory B cells, particularly switched memory B cells, was significantly decreased in rheumatoid arthritis patients with interstitial lung disease, even after adjusting for prednisolone dose.Conclusions: We suspect memory B cells play important roles in interstitial lung disease associated with rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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