Urinary Biomarkers for Screening for Renal Scarring in Children with Febrile Urinary Tract Infection: Pilot Study
| Autor: | Shoji Tsuji, Takahisa Kimata, Shogo Kato, Tetsuya Kitao, Kazunari Kaneko, Sohsaku Yamanouchi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Fever Urology Urinary system Angiotensinogen Pilot Projects Urine Scintigraphy Vesicoureteral reflux Gastroenterology Nephropathy Cicatrix chemistry.chemical_compound Internal medicine Humans Medicine Prospective Studies Child Reflux nephropathy Creatinine medicine.diagnostic_test biology business.industry C-reactive protein Infant medicine.disease Endocrinology chemistry Child Preschool Urinary Tract Infections biology.protein Female Kidney Diseases business Biomarkers |
| Zdroj: | Journal of Urology. 194:766-771 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | Purpose Recurrent febrile urinary tract infections during infancy cause renal scarring, which is characterized by progressive focal interstitial fibrosis and may lead to renal failure. Renal scarring can be diagnosed through scintigraphy, although it seems impractical to perform renal scintigraphy for all infants with febrile urinary tract infections. Therefore, it is important to search for a biomarker to identify the presence of renal scarring. We hypothesized that urinary biomarkers of nephropathy may increase in infants with renal scarring following febrile urinary tract infections. Materials and Methods A total of 49 infants who underwent renal scintigraphy for febrile urinary tract infections were enrolled in the study. Several measurements were performed using urine samples, including total proteins, beta2-microglobulins, N-acetyl-β-D-glucosaminidase, neutrophil gelatinase associated lipocalin, liver-type fatty acid binding protein and angiotensinogen. Values were corrected by creatinine and compared between patients with and without renal scarring. Results Among urinary biomarkers only angiotensinogen in patients with scarring (median 14.6 μg/gm creatinine) demonstrated significantly higher levels than in patients without scarring (3.6 μg/gm creatinine, p Conclusions Urinary angiotensinogen may be useful for diagnosing the presence of renal scarring. |
| Databáze: | OpenAIRE |
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