Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity
| Autor: | David Roura Padrosa, Francesca Paradisi, Karst Eelco Lenzen, Isabelle Feller, Matteo Planchestainer, Martin Albrecht |
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| Rok vydání: | 2021 |
| Předmět: |
Stereochemistry
010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound 540 Chemistry Materials Chemistry Hum Peptide synthesis Amino Acids Peptide sequence Catalytic hydrogenation chemistry.chemical_classification Molecular Structure 010405 organic chemistry Metals and Alloys General Chemistry Small molecule 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Amino acid Chemistry chemistry Ceramics and Composites Reductase activity Oxidoreductases Peptides Methane Carbene |
| Zdroj: | Lenzen, Karst; Planchestainer, Matteo; Feller, Isabelle; Roura Padrosa, David; Paradisi, Francesca; Albrecht, Martin (2021). Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity. Chemical communications, 57(72), pp. 9068-9071. Royal Society of Chemistry 10.1039/D1CC03158A Chemical Communications (Cambridge, England) |
| DOI: | 10.48350/159393 |
| Popis: | Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes. A non-natural histidinium amino acid has been developed and used for solid-phase peptide synthesis to construct a peptide iridium carbene conjugate as artificial mini-peptide for hydrogenation catalysis. |
| Databáze: | OpenAIRE |
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