Relationship Between the Plasma Levels of Brain Natriuretic Peptide and Left Ventricular Ejection Fraction in Asymptomatic Patients With Previous Myocardial Infarction
| Autor: | Motoyuki Onikura, Kaname Hirayanagi, Takehiko Washio, Katsuo Kanmatsuse, Ikuyoshi Watanabe, Toshio Kushiro, Narimichi Kumabe, Shigemasa Tani |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Asymptomatic Ventricular Function Left Internal medicine Natriuretic Peptide Brain Outpatients medicine Humans cardiovascular diseases Myocardial infarction Heart Failure Ejection fraction business.industry Stroke Volume General Medicine Plasma levels Middle Aged Brain natriuretic peptide medicine.disease Cross-Sectional Studies Heart failure Ambulatory cardiovascular system Cardiology Female Negative correlation medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | International Heart Journal. 46:1007-1014 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.46.1007 |
| Popis: | While the usefulness of measuring the plasma levels of brain natriuretic peptide (BNP) in cases with worsening heart failure and severe heart failure has already been established, the benefits of evaluation of this parameter in asymptomatic stable patients with left ventricular dysfunction is still under debate. Left ventricular function was evaluated in 141 ambulatory outpatients with a previous history of myocardial infarction not associated with symptoms of heart failure for at least one year. The plasma BNP level was also determined in these patients for comparative study. No correlation between the plasma level of BNP and EF was noted in the normal-EF group, while a negative correlation between the two parameters was observed in the low-EF group (Y = 0.439 - 0.000266X) (R2 = 0.244, P < 0.0001). The sensitivity was 91.5%, specificity 56.3%, positive predictive accuracy value 61.9%, and negative predictive accuracy value 83.8% for a plasma BNP cut-off level of 89.0 pg/mL. The results suggested that it might be meaningful to measure the plasma BNP level, especially in asymptomatic patients with a previous history of myocardial infarction having a low-EF. |
| Databáze: | OpenAIRE |
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