Effects of butylated hydroxytoluene and acetylaminofluorene on NADPH-cytochrome P-450 reductase activity in rat liver microsomes
| Autor: | Donald D. Gibson, Lora E. Rikans, M. Margaret King, Paul B. McCay |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Cytochrome biology Chemistry Weanling 2-Acetylaminofluorene Butylated Hydroxytoluene In Vitro Techniques Toxicology Dietary Fats In vitro Rats Rat liver microsomes chemistry.chemical_compound Liver Biochemistry Acetylaminofluorene Microsomes Liver biology.protein Animals Butylated hydroxytoluene Nadph cytochrome Reductase activity NADPH-Ferrihemoprotein Reductase |
| Zdroj: | Food and Cosmetics Toxicology. 19:89-92 |
| ISSN: | 0015-6264 |
| DOI: | 10.1016/0015-6264(81)90309-6 |
| Popis: | Cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity were measured in liver microsomes prepared from male weanling rats fed low-fat, high-saturated fat or high-polyunsaturated fat diets with or without butylated hydroxytoluene (BHT) and 2-acetylaminofluorene (AAF). The inclusion of BHT and/or AAF in the diets consistently produced marked decreases in cytochrome P-450 reductase activity, regardless of the amount and type of dietary fat. In contrast, there was no inhibition of reductase activity when the compounds were added in vitro to liver microsomes. |
| Databáze: | OpenAIRE |
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