Long noncoding RNAs: p53's secret weapon in the fight against cancer?

Autor: Ashish Lal, Sarah B. Lazar, Emily A. Dangelmaier
Rok vydání: 2019
Předmět:
0301 basic medicine
Genome instability
Gene Expression
Genome
Biochemistry
Suppressor Genes
law.invention
Computational biology
0302 clinical medicine
law
Neoplasms
DNA Breaks
Double-Stranded
Biology (General)
Regulation of gene expression
Chromosome Biology
General Neuroscience
DNA
Neoplasm
Genomics
Long non-coding RNA
Chromatin
Neoplasm Proteins
Gene Expression Regulation
Neoplastic
Nucleic acids
RNA
Long Noncoding
Epigenetics
General Agricultural and Biological Sciences
Genome complexity
Unsolved Mystery
QH301-705.5
Tumor Suppressor Genes
DNA repair
Biology
General Biochemistry
Genetics and Molecular Biology
Genomic Instability
03 medical and health sciences
Gene Types
Genetics
Humans
Gene Regulation
Non-coding RNA
Gene
Transcription factor
General Immunology and Microbiology
Biology and life sciences
Genome
Human
RNA
Recombinational DNA Repair
Cell Biology
DNA
Non-coding RNA sequences
030104 developmental biology
Long non-coding RNAs
Suppressor
DNA damage
Tumor Suppressor Protein p53
030217 neurology & neurosurgery
Zdroj: PLoS Biology
PLoS Biology, Vol 17, Iss 2, p e3000143 (2019)
ISSN: 1545-7885
Popis: p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53. This raises the possibility that a subset of these genes, regulated by a p53-induced long noncoding RNA (lncRNA), could control p53’s tumor suppressor function. We propose molecular mechanisms through which lncRNAs could regulate this subset of genes and hypothesize an exciting, direct role of lncRNAs in p53’s genome stability maintenance function. Exploring these mechanisms could reveal lncRNAs as indispensable mediators of p53 and lay the foundation for understanding how other transcription factors could act via lncRNAs.
Transcription factors regulate hundreds of genes, a subset of which could mediate its effects in a given context. This Unsolved Mystery article explores mechanisms by which long noncoding RNAs might regulate such a subset downstream of p53, a well-studied transcription factor and major tumor suppressor.
Databáze: OpenAIRE
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