Structure-based design, synthesis and antitumoral evaluation of enulosides

Autor:	Carlos H.B. da Cruz, Paulo H. Menezes, Juliano Carlo Rufino Freitas, Gardenia C.G. Militão, Thiago D S Silva, Teresinha Gonçalves da Silva, João Rufino de Freitas Filho, Cosme Silva Santos, Claudia Lais Araujo Almeida, Jonh Anderson Macêdo Santos
Rok vydání:	2017
Předmět:	Stereochemistry Carbohydrates Antineoplastic Agents Tumor cells 010402 general chemistry 01 natural sciences Structure-Activity Relationship Neoplasms Drug Discovery Tumor Cells Cultured Humans Structure–activity relationship Molecule Cell Proliferation Pharmacology Biological Products Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry General Medicine Carbohydrate Combinatorial chemistry 0104 chemical sciences Design synthesis Drug Design Structure based Drug Screening Assays Antitumor
Zdroj:	European Journal of Medicinal Chemistry. 128:192-201
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2017.01.036
Popis:	Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60 cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f470fa2f0b5afeda7b3dcae5190ae2 https://doi.org/10.1016/j.ejmech.2017.01.036 Zobrazit plný text záznamu Full Text from ScienceDirect