A cell‐centric view of lung alveologenesis
| Autor: | Jichao Chen, Lisandra Vila Ellis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Lung Organogenesis Lung morphology Biology Article Pulmonary Alveoli 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Animals Humans Regeneration Chest cavity Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Dev Dyn |
| ISSN: | 1097-0177 1058-8388 |
| Popis: | Lung alveologenesis, formation of the alveolar region, allows sufficient gas exchange surface to be packed inside the chest cavity yet with orderly connection to the trachea. The real-life alveolar region, however, bears little resemblance to idealized cartoons owing to its three-dimensional nature, non-uniform shape, and mostly air-filled void. This morphological complexity is matched by its cellular complexity - comprised of intermixed and often tangled cells of the epithelial, mesenchymal, endothelial, and immune lineages. Modern imaging, genetics, and genomics are shedding light on and updating traditional views of alveologenesis. Accordingly, this review describes a cell-centric 3-phase definition of alveologenesis and discusses its failure in diseases and possible reactivation during regeneration. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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