High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
| Autor: | Tao Qin, Qiu Fan Zheng, Zhong Yu Yuan, Fei Xu, Yin Duo Zeng, Cong Xue, Rou Jun Peng, Li Zhang, Jian Hua Zhan, Jia Bin Lu, Ge Qin, Wenfeng Fang, S. Wang, Xin Ke Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
PD-L1 Adult medicine.medical_specialty Pathology China Lymphovascular invasion Breast Neoplasms Kaplan-Meier Estimate PR B7-H1 Antigen Disease-Free Survival Metastasis nomogram Young Adult Breast cancer breast cancer Internal medicine Statistical significance medicine Humans Young adult Neoplasm Metastasis Aged Proportional Hazards Models Aged 80 and over business.industry Proportional hazards model Cancer Nomogram Middle Aged medicine.disease Prognosis Immunohistochemistry Gene Expression Regulation Neoplastic Nomograms Treatment Outcome ER Lymphatic Metastasis Multivariate Analysis Regression Analysis Female Clinical Research Paper Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Tao Qin 1,* , Yin-duo Zeng 1,2,* , Ge Qin 1,* , Fei Xu 1,* , Jia-bin Lu 1 , Wen-feng Fang 1 , Cong Xue 1 , Jian-hua Zhan 1 , Xin-ke Zhang 1 , Qiu-fan Zheng 1 , Rou-jun Peng 1 , Zhong-yu Yuan 1 , Li Zhang 1 and Shu-sen Wang 1 1 Sun Yat-sen University Cancer Center, The State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China 2 Sun Yat-sen University Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong, P. R. China * These authors have contributed equally to this work Correspondence to: Shu-sen Wang, email: // Li Zhang, email: // Zhong-yu Yuan, email: // Keywords : PD-L1, breast cancer, ER, PR, prognosis, nomogram Received : July 07, 2015 Accepted : August 22, 2015 Published : September 10, 2015 Abstract Background: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. Methods: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. Results: The median follow-up time was 98 months(range, 17–265 months).The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. Conclusions: PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients. |
| Databáze: | OpenAIRE |
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