Autor: |
M. A. Kozlova, I. I. Faingold, Alexander V. Zhilenkov, D. A. Areshidze, R. A. Kotel’nikova, P. A. Troshin, S. M. Aldoshin, Yu. V. Soldatova |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
Doklady Biochemistry and Biophysics. 488:320-323 |
ISSN: |
1608-3091 1607-6729 |
Popis: |
It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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