Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

Autor:	M. A. Kozlova, I. I. Faingold, Alexander V. Zhilenkov, D. A. Areshidze, R. A. Kotel’nikova, P. A. Troshin, S. M. Aldoshin, Yu. V. Soldatova
Rok vydání:	2019
Předmět:	L-Iditol 2-Dehydrogenase Sorbitol dehydrogenase Potassium Drug Evaluation Preclinical Biophysics Salt (chemistry) chemistry.chemical_element Pharmacology Biochemistry Diabetes Mellitus Experimental Mice 03 medical and health sciences Aldehyde Reductase Diabetes mellitus medicine Animals Hypoglycemic Agents Bovine serum albumin 030304 developmental biology chemistry.chemical_classification 0303 health sciences Aldose reductase biology 030302 biochemistry & molecular biology Type 2 Diabetes Mellitus General Chemistry General Medicine medicine.disease Enzyme Diabetes Mellitus Type 2 chemistry biology.protein
Zdroj:	Doklady Biochemistry and Biophysics. 488:320-323
ISSN:	1608-3091 1607-6729
Popis:	It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f185098eb601ff7bc1c759e02224aa https://doi.org/10.1134/s1607672919050089 Zobrazit plný text záznamu Plný text ve formátu PDF