Aging and bone health in Singaporean Chinese pre-menopausal and postmenopausal women

Autor: William G. Hart, Victor H.H. Goh
Rok vydání: 2016
Předmět:
musculoskeletal diseases
0301 basic medicine
Adult
medicine.medical_specialty
Aging
Hormone Replacement Therapy
medicine.medical_treatment
Osteoporosis
Population
030209 endocrinology & metabolism
General Biochemistry
Genetics and Molecular Biology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Asian People
Bone Density
Internal medicine
medicine
Prevalence
Humans
education
Exercise
Femoral neck
Aged
Bone mineral
education.field_of_study
Singapore
Lumbar Vertebrae
business.industry
Femur Neck
Obstetrics and Gynecology
Hormone replacement therapy (menopause)
Middle Aged
musculoskeletal system
medicine.disease
Menopause
Postmenopause
medicine.anatomical_structure
Cross-Sectional Studies
Adipose Tissue
Premenopause
Physical therapy
Lean body mass
Female
030101 anatomy & morphology
business
Body mass index
Zdroj: Maturitas. 89
ISSN: 1873-4111
Popis: Objective The study evaluated relationships between menopausal statuses, hormone replacement therapy (HRT), body mass index (BMI), percent body fat (PBF), and exercise with osteoporosis and bone mineral density (BMD) in Singaporean women. Study design This is a cross-sectional study. Main outcome measures The spine BMD, and femoral neck BMD as well as the prevalence of osteoporosis are the main outcome measures studied. Results Age, BMI, PBF and exercise intensity were independently associated with spine and femoral neck BMD. Women with higher BMI and lower PBF had higher BMD and lower prevalence of osteoporosis. Postmenopausal women without HRT had lower BMD and higher prevalence of osteoporosis while those on HRT had similar BMD and prevalence of osteoporosis as premenopausal women. Conclusion This study shows that BMI and PBF are powerful predictors of BMD. Osteoporosis is site-specific in the Singapore population, being higher in the femoral neck than in the lumbar spine. The bone status after menopause may not be worse than that dictated by age alone and both ERT and E/PRT could sustain the BMD to levels corresponding to those of women a decade younger. A strategy to improve bone health should include dieting and physical exercise program that focuses on selectively reducing fat mass and increasing lean mass.
Databáze: OpenAIRE
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