Copper/Zinc Superoxide Dismutase in Human Skin: Current Knowledge
| Autor: | Giovanna Giuseppina Altobelli, Vincenzo Cimini, Anna Balato, Susan Van Noorden |
|---|---|
| Přispěvatelé: | Altobelli, G. G., Van Noorden, S., Balato, A., Cimini, V. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Cu/Zn superoxide dismutase Mini Review chemistry.chemical_element Human skin Zinc medicine.disease_cause Superoxide dismutase 03 medical and health sciences 0302 clinical medicine medicine chemistry.chemical_classification lcsh:R5-920 Reactive oxygen species integumentary system biology ROS General Medicine skin tumors 030104 developmental biology Enzyme chemistry Biochemistry 030220 oncology & carcinogenesis biology.protein immunochemistry Medicine Signal transduction human skin lcsh:Medicine (General) Oxidative stress |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, Vol 7 (2020) |
| Popis: | Superoxide dismutase is widespread in the human body, including skin and its appendages. Here, we focus on human skin copper/zinc superoxide dismutase, the enzyme that protects skin and its appendages against reactive oxygen species. Human skin copper/zinc superoxide dismutase resides in the cytoplasm of keratinocytes, where up to 90% of cellular reactive oxygen species is produced. Factors other than cell type, such as gender, age and diseased state influence its location in skin tissues. We review current knowledge of skin copper/zinc superoxide dismutase including recent studies in an attempt to contribute to solving the question of its remaining unexplained functions. The research described here may be applicable to pathologies associated with oxidative stress. However, recent studies on copper/zinc superoxide dismutase in yeast reveal that its predominant function may be in signaling pathways rather than in scavenging superoxide ions. If confirmed in the skin, novel approaches might be developed to unravel the enzyme's remaining mysteries. |
| Databáze: | OpenAIRE |
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