The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor

Autor:	Alison I. Muir, Izzy Boyfield, Kalindi Vaidya, Barry Sidney Orlek, Etienne Fleury, David G. Evans, Jackie S. Scott, Hindy Mok, Victoria J. Bolton, Ward John Gerard, Geoffrey Stemp, Tom D. Heightman, Kim L. Matthews, Kirk Lawless, Gareth J. Sanger, Fiona McKay, Alexander J. Stevens, Emma M. Jarvie, James Matthew Bailey, Susan Marie Westaway, Mervyn Thompson, Jonathan B. Basilla
Rok vydání:	2009
Předmět:	Receptors Neuropeptide Agonist medicine.drug_class Stereochemistry Chemistry Pharmaceutical High-throughput screening Motilin receptor Clinical Biochemistry Pharmaceutical Science CHO Cells Pharmacology Biochemistry Chemical synthesis Receptors Gastrointestinal Hormone Motilin Benzazepine Structure-Activity Relationship chemistry.chemical_compound Cricetulus Cricetinae Drug Discovery medicine Animals Sulfones Molecular Biology G protein-coupled receptor chemistry.chemical_classification Sulfonamides Binding Sites Molecular Structure Chemistry digestive oral and skin physiology Organic Chemistry Sulfonamide Models Chemical Drug Design Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:6452-6458
ISSN:	0960-894X
Popis:	Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f11cdd038a55294786dd33de3ee625 https://doi.org/10.1016/j.bmcl.2009.09.027 Zobrazit plný text záznamu Full Text from ScienceDirect