Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?
| Autor: | Coen D.A. Stehouwer, Marina L. H. Honing |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CARIM School for Cardiovascular Diseases |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Endothelium Homocysteine Arteriosclerosis Hyperhomocysteinemia Clinical science Disease Bioinformatics chemistry.chemical_compound Folic Acid Risk Factors Internal medicine medicine Humans Risk factor business.industry General Medicine Clinical disease Endocrinology medicine.anatomical_structure Increased risk chemistry Cardiovascular Diseases Endothelium Vascular business Function (biology) |
| Zdroj: | Clinical Science, 106(4), 345-346. Portland Press Ltd. |
| ISSN: | 0143-5221 |
| Popis: | Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?Honing ML, Stehouwer CD.Department of Internal Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands.The majority of clinical studies demonstrate that patients with hyperhomocysteinaemia have an increased risk of atherothrombotic events. However, there is a striking and poorly understood heterogeneity in the severity of clinical features in individuals with hyperhomocysteinaemia. This observation suggests that other factors must exist that modulate the relationship between hyperhomocysteinaemia and clinical disease. Therefore identifying factors that inhibit or enhance the vasculotoxic effects of homocysteine is important, as is elucidation of how homocysteine damages blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial function |
| Databáze: | OpenAIRE |
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