Upregulation of histidine decarboxylase mRNA expression in scleroderma skin
| Autor: | Shigeru Matsuzaki, Tsutomu Ohtsuka, Soji Yamazaki, Hideki Ohtake, Akio Yamakage, Atsushi Ichikawa, Kaoru Ichimura |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Carboxy-lyases Cell Gene Expression Dermatology In situ hybridization Histidine Decarboxylase Biology Pathogenesis chemistry.chemical_compound Downregulation and upregulation medicine Humans Tissue Distribution RNA Messenger skin and connective tissue diseases In Situ Hybridization Skin Messenger RNA Scleroderma Systemic integumentary system Osmolar Concentration General Medicine Middle Aged Blotting Northern Histidine decarboxylase Molecular biology Up-Regulation medicine.anatomical_structure chemistry Immunology Female Histamine |
| Zdroj: | Archives of Dermatological Research. 293:171-177 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/s004030100206 |
| Popis: | The involvement of histamine in the pathogenesis of systemic sclerosis (SSc) has been suggested. Possible involvement of histamine and histidine decarboxylase (HDC), the synthesizing enzyme for histamine, in the formation of the skin abnormalities in SSc was studied. Skin histamine concentrations in SSc were significantly lower than in normal controls (P < 0.02). In situ hybridization with an HDC probe revealed that the expression of the HDC gene in SSc was greater than in normal controls. The number of cells and the mean grain number per cell expressing HDC mRNA were both significantly greater in SSc than in normal controls (both P < 0.01). These results show a reduction in histamine concentration and an elevated HDC gene expression in SSc skin, indicating an increase in both histamine release and HDC gene expression. The upregulation of histamine turnover appears to be involved in the formation of the skin abnormalities of SSc. |
| Databáze: | OpenAIRE |
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