Advanced carotid plaque imaging
| Autor: | Linda Hermus, Clark J. Zeebregts, van Gooitzen Dam |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
EXPRESSION
Diagnostic Imaging medicine.medical_specialty medicine.medical_treatment Molecular imaging Contrast Media Apoptosis Near-infrared fluorescence Single-photon emission computed tomography medicine.disease_cause DISEASE POSITRON-EMISSION-TOMOGRAPHY Carotid artery disease medicine Humans Carotid Stenosis Vulnerable plaque IN-VIVO ATHEROSCLEROTIC PLAQUES ARTERY Endarterectomy Computed tomography angiography Medicine(all) Inflammation medicine.diagnostic_test business.industry HIGH-RESOLUTION MRI Magnetic resonance imaging medicine.disease Atherosclerosis Stenosis Cerebrovascular Disorders ISCHEMIC-STROKE Positron emission tomography Surgery Radiology MATRIX-METALLOPROTEINASE Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Carotid artery Biomarkers Peptide Hydrolases |
| Zdroj: | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 39(2) |
| ISSN: | 1532-2165 |
| Popis: | Treatment of carotid artery stenosis by endarterectomy or stenting can significantly reduce stroke risk. In clinical practice, indication for surgery or stenting is primarily based on the degree of stenosis, but there is growing awareness that pathophysiological features within a vulnerable plaque play a key role in predicting stroke risk. Important molecular processes associated with plaque vulnerability are inflammation, lipid accumulation, proteolysis, apoptosis, angiogenesis and thrombosis. The rapidly emerging field of molecular and functional imaging strategies allows identification of pathophysiological processes in carotid artery stenosis. We aimed to review the literature regarding the current most promising advanced imaging techniques in carotid artery disease. Various advanced imaging methods are available, such as high-resolution magnetic resonance imaging (HR-MRI), single photon emission computed tomography (SPECT), positron emission tomography (PET) and near-infrared fluorescence (NIRF). Radionuclide and fluorescent tracers that identify inflammation, apoptosis and proteolysis, such as FDG, MMP probes and Annexin A5, are promising. A combination of activity of molecular processes and detailed anatomic information can be obtained, providing a powerful tool in the identification of the vulnerable plaque. With these developments, we are entering a new era of imaging techniques in the selection of patients for carotid surgery. (C) 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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