Synthetic Approaches Towards the Marine Alkyl Purines
| Autor: | Gordaliza M, Baraldi Pg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Purine
asmarine Stereochemistry Guanidines Biochemistry ageloxime NO Broad spectrum chemistry.chemical_compound Drug Discovery Alkyl purine Animals Humans Moiety Organic chemistry ageline Purine metabolism Alkyl terpene purine gelasine Pharmacology chemistry.chemical_classification biology Organic Chemistry agelasimine Alkyl purine terpene purine agelasine ageline ageloxime gelasine agelasimine asmarine nuttingin malonganenone Leptogorgia biology.organism_classification agelasine chemistry nuttingin Purines malonganenone Molecular Medicine Diterpenes |
| Popis: | Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety. |
| Databáze: | OpenAIRE |
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