Bone edema on magnetic resonance imaging is highly associated with low bone mineral density in patients with ankylosing spondylitis

Autor: Ling Lin, Yao Gong, Su-Biao Chen, Dan-Min Wang, Zheng-Yu Xiao, Zhi-Duo Hou
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Bone density
Ankylosing Spondylitis
Osteoporosis
lcsh:Medicine
Pathology and Laboratory Medicine
Diagnostic Radiology
0302 clinical medicine
Absorptiometry
Photon
Bone Density
Risk Factors
Medicine and Health Sciences
Edema
Femur
lcsh:Science
Musculoskeletal System
Immune Response
Bone Marrow Diseases
Sacroiliac joint
Bone mineral
Multidisciplinary
Radiology and Imaging
musculoskeletal system
Magnetic Resonance Imaging
Bone Imaging
medicine.anatomical_structure
Connective Tissue
Female
Anatomy
Research Article
musculoskeletal diseases
Adult
Adolescent
Imaging Techniques
Immunology
Research and Analysis Methods
Autoimmune Diseases
Pelvis
03 medical and health sciences
Young Adult
Signs and Symptoms
Diagnostic Medicine
medicine
Humans
Spondylitis
Ankylosing
Bone
Spondylitis
Skeleton
030203 arthritis & rheumatology
Inflammation
Ankylosing spondylitis
Hip
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Spine
Osteopenia
030104 developmental biology
Biological Tissue
Case-Control Studies
lcsh:Q
Clinical Immunology
Clinical Medicine
business
Nuclear medicine
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189569 (2017)
ISSN: 1932-6203
Popis: Objective This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). Methods The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed. Lumbar spine and proximal femur BMD were assessed using dual-energy X-ray absorptiometry. Low BMD was defined by a Z-score ≤-2. The Spondyloarthritis Research Consortium of Canada (SPARCC) MRI index was used to assess inflammation at the sacroiliac joint (SIJ) and spine. Results Among the 333 patients, the male:female ratio was 4.6:1, mean patient age was 28.5±10.6 years, and mean disease duration was 7.3±6.8 years. The prevalences of low BMD, osteopenia, and osteoporosis were significantly higher among AS patients than among controls (19.8%, 62.8%, and 5.7% vs. 4.7%, 33.0%, and 0%, respectively, P = 0.000). The BMD values were significantly lower and prevalences of low BMD at both the spine and femur were significantly higher among patients with BME on MRI than among those without BME. Multivariate logistic regression analysis showed that male sex (OR 3.87, 95% CI 1.21-7.36, P = 0.023), high ASDAS-CRP score (OR 2.83, 95% CI 1.36-4.76, P = 0.015), the presence of BME on sacroiliac MRI (OR 2.83, 95% CI 1.77-6.23, P = 0.000) and spinal MRI (OR 4.06, 95% CI 1.96-8.46, P = 0.000), and high grade of sacroiliitis (OR 2.93, 95% CI 1.82-4.45, P = 0.002) were risk factors for low BMD (any site). The SPARCC scores of the SIJ were negatively correlated with femoral BMD (r = -0.22, 95% CI -0.33 to -0.10, P = 0.000). Additionally, the SPARCC scores of the spine were negatively correlated with BMD values (r = -0.23, 95% CI -0.36 to -0.09, P = 0.003) and Z-scores (r = -0.24, 95% CI -0.36 to -0.12, P = 0.001) at the spine. Conclusion Low BMD is common in AS patients. BME on MRI is highly associated with low BMD at both the spine and femur.
Databáze: OpenAIRE
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