Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison
| Autor: | K Otsa, T Veldi, Silvia Capellino, Maurizio Cutolo, Barbara Villaggio, Alberto Sulli, L. Fazzuoli, O. Aakre, Georges J.M. Maestroni, T Peets, E Hertens, Paola Montagna |
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| Rok vydání: | 2005 |
| Předmět: |
rheumatoid arthritis
Male hydrocortisone blood level Hydrocortisone circadian rhythm cytokine production disease duration disease severity hydrocortisone blood level hypothalamus hypophysis adrenal system radioimmunoassay rheumatoid arthritis Interleukin-6 Tumor Necrosis Factor-alpha Arthritis Rheumatoid Immunology and Allergy Melatonin radioimmunoassay biology Radioimmunoassay Middle Aged Circadian Rhythm Extended Report Italy Rheumatoid arthritis cytokine production Corticosteroid disease severity Female Seasons hormones hormone substitutes and hormone antagonists medicine.drug Adult Estonia endocrine system medicine.medical_specialty hypothalamus hypophysis adrenal system medicine.drug_class Photoperiod Immunology General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine medicine Humans Circadian rhythm Interleukin 6 Aged Interleukin-6 Tumor Necrosis Factor-alpha business.industry Case-control study medicine.disease Endocrinology Case-Control Studies biology.protein disease duration business |
| Zdroj: | Annals of the Rheumatic Diseases. 64:212-216 |
| ISSN: | 0003-4967 |
| Popis: | Background: Altered functioning of the hypothalamic-pituitary-adrenal axis and altered melatonin production might modulate the circadian symptoms in patients with rheumatoid arthritis. Objective: To investigate the influence of different winter photoperiods on the circadian rhythms of serum melatonin, cortisol, tumour necrosis factor α (TNFα), and interleukin 6 (IL6) in patients with rheumatoid arthritis from a north Europe country (Estonia) and a south Europe country (Italy). Methods: The patients from Estonia (n = 19) and Italy (n = 7) had similar disease severity and duration and were compared with healthy age and sex matched controls in the two countries. Blood samples were collected during the period January to February at 8 pm, 10 pm, midnight, 2 am, 4 am, 6 am, 8 am, and 3 pm. Melatonin was measured by radioimmunoassay using 125I-melatonin. Serum cortisol, TNFα, and IL6 cytokines were assayed by standard methods. Results: Higher circadian melatonin concentrations from 10 pm and an earlier peak were observed in Estonian patients than in their age and sex matched controls (p |
| Databáze: | OpenAIRE |
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