MRI evaluation of the hydration status of non-pathological lumbar intervertebral discs in a pediatric population

Autor: Manon Bolzinger, Pascal Swider, Jérôme Sales de Gauzy, Eva Polirsztok, Christiane Baunin, Kariman Abelin-Genevois, Erik Estivalèzes, Adeline Gallini
Přispěvatelé: Institut de mécanique des fluides de Toulouse (IMFT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CMCR des Massues, Croix rouge française, (OATAO), Open Archive Toulouse Archive Ouverte, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Centre Hospitalier Universitaire de Nancy - CHU Nancy (FRANCE), Centre Médico-Chirurgical de Réadaptation des Massues - CMCR des Massues (FRANCE), Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Rok vydání: 2018
Předmět:
musculoskeletal diseases
Male
medicine.medical_specialty
Adolescent
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Mécanique des fluides
Médecine humaine et pathologie
Intervertebral Disc Degeneration
Asymptomatic
03 medical and health sciences
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
0302 clinical medicine
Lumbar
Image processing
medicine
Humans
Orthopedics and Sports Medicine
Intervertebral Disc
Pathological
Hydration status
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
030222 orthopedics
Lumbar Vertebrae
business.industry
Lumbosacral Region
Intervertebral disc
030229 sport sciences
musculoskeletal system
Magnetic Resonance Imaging
Confidence interval
Surgery
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Scoliosis
Female
medicine.symptom
Nuclear medicine
business
Lumbosacral joint
MRI
Pediatric population
Zdroj: Orthopaedics and Traumatology-Surgery and Research
Orthopaedics and Traumatology-Surgery and Research, Elsevier, 2020, 106 (7), pp.1281-1285. ⟨10.1016/j.otsr.2019.11.034⟩
Orthopaedics & Traumatology: Surgery & Research
Orthopaedics & Traumatology: Surgery & Research, 2020, 106 (7), pp.1281-1285. ⟨10.1016/j.otsr.2019.11.034⟩
ISSN: 1877-0568
DOI: 10.1016/j.otsr.2019.11.034⟩
Popis: Introduction The intervertebral disc (IVD) is made up of the annulus fibrosus (AF) and the nucleus pulposus (NP) – an inert hydrated complex. The ability of the IVD to deform is correlated to that of the NP and depends on its hydration. As the IVD ages, its hydration decreases along with its ability to deform. In adolescent idiopathic scoliosis, one of the etiological hypotheses pertains to the IVD, thus making its condition relevant for the diagnosis and monitoring of this pathology. Hypothesis IVD hydration depends on sex, age and spine level in an asymptomatic pediatric population. The corollary is data on a control group of healthy subjects. Material and methods A cohort of 98 subjects with normal spine MRI was enrolled; their mean age was 13.3 years. The disc volume and hydration of each IVD was evaluated on T2-weighted MRI sequences, using previously validated image processing software. This evaluation focused on the lumbar spine, from the thoracolumbar junction to the lumbosacral junction. It was assumed that IVD hydration was related to the ratio of NP and AF volumes. A mixed multivariate linear analysis was used to explore the impact of age, sex and spinal level on disc hydration. Results Disc hydration was higher overall in boys than in girls, but this difference was not significant. Hydration increased with age by +0.005 for each additional year (p = 0.0213). Disc hydration appears to be higher at the thoracolumbar junction than the lumbar spine, although this difference was not significant. Conclusion Through this MRI study, we established a database of non-pathological lumbar disc hydration as a function of age, sex and spinal segment along with 95% confidence intervals. Level of evidence IV.
Databáze: OpenAIRE
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