Primary cardiac tumors: a clinicopathologic evaluation of four cases
| Autor: | Vera Timmermans-Wielenga, Charlotte Winther, Svend Aage Mortensen, Kåre Sander, Claus B. Andersen, Søren Daugaard |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Leiomyosarcoma
Adult Male medicine.medical_specialty medicine.medical_treatment Chest pain Undifferentiated Pleomorphic Sarcoma Pathology and Forensic Medicine Heart Neoplasms medicine Humans Pathological Retrospective Studies Heart transplantation business.industry Medical record Retrospective cohort study Sarcoma General Medicine Middle Aged medicine.disease Immunohistochemistry Surgery Heart Transplantation Female medicine.symptom Neoplasm Recurrence Local Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 20(1) |
| ISSN: | 1879-1336 |
| Popis: | Introduction We report the clinical, pathological, and immunohistochemical features of four primary malignant cardiac tumors identified at the Department of Pathology, Rigshospitalet, Denmark. A panel of immunohistochemical markers for classification is proposed. Methods Between 2000 and 2008, four patients with malignant cardiac tumors were treated at our hospital. We retrospectively reviewed the medical records and evaluated the patient characteristics and treatment. Results Three patients presented with severe dyspnea; one patient presented with chest pain. Transthoracic echocardiography demonstrated, in all four cases, abnormal masses in the atria. The cases were, based on morphological features and immunoprofile, classified as myogenic sarcoma (two cases), undifferentiated pleomorphic sarcoma, and leiomyosarcoma. Three of the patients received orthotopic heart transplantation. One patient survived 6.5 years after the diagnosis, and two patients are still alive 2 and 3 years after being diagnosed, respectively. Conclusions All four cases were sarcomas. A limited number of immunohistochemical markers can be used in order to define a specific line of differentiation. In this small study, three of the patients were offered orthotopic heart transplantation, and the survival times were generally longer than in most series. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect