Dentine is biochemically abnormal in osteogenesis imperfecta
| Autor: | John P. Gage, Roger Smith, Gill E. Whitaker, Martin J. O. Francis |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Lysine Glycine Dentistry chemistry.chemical_compound stomatognathic system Internal medicine Dentin medicine Humans Amino Acids Permanent teeth business.industry General Medicine Osteogenesis Imperfecta medicine.disease Control subjects Osteochondrodysplasia stomatognathic diseases Hydroxylysine Hydroxyproline medicine.anatomical_structure Endocrinology chemistry Amino acid composition Osteogenesis imperfecta business |
| Zdroj: | Clinical science (London, England : 1979). 70(4) |
| ISSN: | 0143-5221 |
| Popis: | 1. In osteogenesis imperfecta the bones are brittle but the teeth, whose dentine contains the same genetic collagen as bone (type I), may be clinically normal. 2. To investigate this paradox we have measured the amino acid composition of insoluble dentine collagen from 16 deciduous and 18 permanent teeth in control subjects and in 59 patients with different forms of osteogenesis imperfecta. 3. In 55 of the patient samples significant differences from normal were found, especially in the number of lysine residues, and in the relative amounts of hydroxylysine to lysine. 4. These results demonstrate the high frequency of biochemical abnormalities in osteogenesis imperfecta. They also suggest that classifications of this disorder based on the presence or absence of clinical dentiogenesis imperfecta are likely to be unsound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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