Lipid Rafts and Dopamine Receptor Signaling
| Autor: | Andrew C Tiu, Laureano D. Asico, Victor J Martinez, Pedro A. Jose |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
G protein Dopamine Blood Pressure Review 030204 cardiovascular system & hematology Kidney Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Membrane Microdomains medicine dopamine receptor Humans Physical and Theoretical Chemistry Receptor Molecular Biology Lipid raft lcsh:QH301-705.5 Spectroscopy lipid rafts Chemistry Effector Receptors Dopamine D2 Receptors Dopamine D1 Organic Chemistry Dopaminergic Cell Membrane Sodium General Medicine medicine.disease Computer Science Applications Cell biology 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Dopamine receptor Hypertension Signal transduction signaling Kidney disease Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 8909, p 8909 (2020) |
| ISSN: | 1422-0067 |
| Popis: | The renal dopaminergic system has been identified as a modulator of sodium balance and blood pressure. According to the Centers for Disease Control and Prevention, in 2018 in the United States, almost half a million deaths included hypertension as a primary or contributing cause. Renal dopamine receptors, members of the G protein-coupled receptor family, are divided in two groups: D1-like receptors that act to keep the blood pressure in the normal range, and D2-like receptors with a variable effect on blood pressure, depending on volume status. The renal dopamine receptor function is regulated, in part, by its expression in microdomains in the plasma membrane. Lipid rafts form platforms within the plasma membrane for the organization and dynamic contact of molecules involved in numerous cellular processes such as ligand binding, membrane sorting, effector specificity, and signal transduction. Understanding all the components of lipid rafts, their interaction with renal dopamine receptors, and their signaling process offers an opportunity to unravel potential treatment targets that could halt the progression of hypertension, chronic kidney disease (CKD), and their complications. |
| Databáze: | OpenAIRE |
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